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Title:

Role of IL-6 in the commitment of T cell subsets.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Korn, Thomas; Hiltensperger, Michael
Abstract:
IL-6 gained much attention with the discovery that this cytokine is a non-redundant differentiation factor for Th17 cells and T follicular helper cells. Adaptive immune responses to fungi and extracellular bacteria are impaired in the absence of IL-6. IL-6 is also required for the induction of ROR-γt+ Treg cells, which are gatekeepers of homeostasis in the gut lamina propria in the presence of commensal bacteria. Conversely, severe immunopathology in T cell-mediated autoimmunity is mediated by T...     »
Journal title abbreviation:
Cytokine
Year:
2021
Journal volume:
146
Fulltext / DOI:
doi:10.1016/j.cyto.2021.155654
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34325116
Print-ISSN:
1043-4666
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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