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Document type:
journal article 
Author(s):
Ziegler, Paul K; Bollrath, Julia; Pallangyo, Charles K; Matsutani, Takaji; Canli, Özge; De Oliveira, Tiago; Diamanti, Michaela A; Müller, Nina; Gamrekelashvili, Jaba; Putoczki, Tracy; Horst, David; Mankan, Arun K; Öner, Meryem G; Müller, Susanna; Müller-Höcker, Josef; Kirchner, Thomas; Slotta-Huspenina, Julia; Taketo, M Mark; Reinheckel, Thomas; Dröse, Stefan; Larner, Andrew C; Wels, Winfried S; Ernst, Matthias; Greten, Tim F; Arkan, Melek C; Korn, Thomas; Wirth, Dagmar; Greten, Florian R 
Title:
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis. 
Abstract:
In colorectal cancer patients, a high density of cytotoxic CD8 T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach in two wnt/?-catenin-dependent autochthonous models of sporadic intestinal tumorigenesis, we unravel a complex intracellular process in intestinal epithelial cells (IECs) that controls the induction of a CD8 T cell based adaptive immune response. Elevated mitophagy in IECs causes iron(II)-accumulation in epithelial lysosomes, in turn, trigg...    »
 
Journal title abbreviation:
Cell 
Year:
2018 
Journal volume:
174 
Journal issue:
Pages contribution:
88-101.e16 
Language:
eng 
Print-ISSN:
0092-8674 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie; Lehrstuhl für Molekulare Neuroimmunologie (Prof. Korn)