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Titel:

Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Knier, Benjamin; Rothhammer, Veit; Heink, Sylvia; Puk, Oliver; Graw, Jochen; Hemmer, Bernhard; Korn, Thomas
Abstract:
Optic neuritis is a common inflammatory manifestation of multiple sclerosis (MS). In experimental autoimmune encephalomyelitis (EAE), the optic nerve is affected as well. Here, we investigated whether autoimmune inflammation in the optic nerve is distinct from inflammation in other parts of the central nervous system (CNS). In our study, inflammatory infiltrates in the optic nerve and the brain were characterized by a high fraction of Ly6G(+) granulocytes whereas in the spinal cord, macrophage i...     »
Zeitschriftentitel:
J Autoimmun
Jahr:
2015
Band / Volume:
56
Seitenangaben Beitrag:
34-44
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jaut.2014.09.003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25282335
Print-ISSN:
0896-8411
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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