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Title:

Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lutz, Konstantin; Musumeci, Andrea; Sie, Christopher; Dursun, Ezgi; Winheim, Elena; Bagnoli, Johannes; Ziegenhain, Christoph; Rausch, Lisa; Bergen, Volker; Luecken, Malte D; Oostendorp, Robert A J; Schraml, Barbara U; Theis, Fabian J; Enard, Wolfgang; Korn, Thomas; Krug, Anne B
Abstract:
Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in earlier and later progenitor stages. Cells within the CD11c+MHCII-/loSiglec-H+CCR9lo DC precursor fraction of the mouse bone marrow generate both pDCs and cDCs. Here we investigate the heterogeneity and commitment of subsets in this compartment by single-cell transcriptomics and high-dimensional flow cytometry combined with cell fa...     »
Journal title abbreviation:
Nat Commun
Year:
2022
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-022-31054-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35705536
Print-ISSN:
2041-1723
TUM Institution:
594; Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie; Molekulare Immunologie (Prof. Knolle)
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