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Title:

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Document type:
Journal Article
Author(s):
Ziegler, Paul K; Bollrath, Julia; Pallangyo, Charles K; Matsutani, Takaji; Canli, Ozge; De Oliveira, Tiago; Diamanti, Michaela A; Müller, Nina; Gamrekelashvili, Jaba; Putoczki, Tracy; Horst, David; Mankan, Arun K; Öner, Meryem G; Müller, Susanna; Müller-Höcker, Josef; Kirchner, Thomas; Slotta-Huspenina, Julia; Taketo, M Mark; Reinheckel, Thomas; Dröse, Stefan; Larner, Andrew C; Wels, Winfried S; Ernst, Matthias; Greten, Tim F; Arkan, Melek C; Korn, Thomas; Wirth, Dagmar; Greten, Florian R
Abstract:
In colorectal cancer patients, a high density of cytotoxic CD8 T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach in two wnt/?-catenin-dependent autochthonous models of sporadic intestinal tumorigenesis, we unravel a complex intracellular process in intestinal epithelial cells (IECs) that controls the induction of a CD8 T cell based adaptive immune response. Elevated mitophagy in IECs causes iron(II)-accumulation in epithelial lysosomes, in turn, trigg...     »
Journal title abbreviation:
Cell
Year:
2018
Journal volume:
174
Journal issue:
1
Pages contribution:
88-101.e16
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2018.05.028
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29909986
Print-ISSN:
0092-8674
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Molekulare Immunologie (Prof. Knolle)
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