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Titel:

Formation and immunomodulatory function of meningeal B cell aggregates in progressive CNS autoimmunity.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Mitsdoerffer, Meike; Di Liberto, Giovanni; Dötsch, Sarah; Sie, Christopher; Wagner, Ingrid; Pfaller, Monika; Kreutzfeldt, Mario; Fräßle, Simon; Aly, Lilian; Knier, Benjamin; Busch, Dirk H; Merkler, Doron; Korn, Thomas
Abstract:
Meningeal B lymphocyte aggregates have been described in autopsy material of patients with chronic multiple sclerosis. The presence of meningeal B cell aggregates has been correlated with worse disease. However, the functional role of these meningeal B cell aggregates is not understood. Here, we use a mouse model of multiple sclerosis, the spontaneous opticospinal encephalomyelitis model, which is built on the double transgenic expression of myelin oligodendrocyte glycoprotein-specific T-cell an...     »
Zeitschriftentitel:
Brain
Jahr:
2021
Band / Volume:
144
Heft / Issue:
6
Seitenangaben Beitrag:
1697-1710
Volltext / DOI:
doi:10.1093/brain/awab093
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33693558
Print-ISSN:
0006-8950
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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