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Titel:

Cognate microglia-T cell interactions shape the functional regulatory T cell pool in experimental autoimmune encephalomyelitis pathology.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Haimon, Zhana; Frumer, Gal Ronit; Kim, Jung-Seok; Trzebanski, Sébastien; Haffner-Krausz, Rebecca; Ben-Dor, Shifra; Porat, Ziv; Muschaweckh, Andreas; Chappell-Maor, Louise; Boura-Halfon, Sigalit; Korn, Thomas; Jung, Steffen
Abstract:
Microglia, the parenchymal brain macrophages of the central nervous system, have emerged as critical players in brain development and homeostasis. The immune functions of these cells, however, remain less well defined. We investigated contributions of microglia in a relapsing-remitting multiple sclerosis paradigm, experimental autoimmune encephalitis in C57BL/6 x SJL F1 mice. Fate mapping-assisted translatome profiling during the relapsing-remitting disease course revealed the potential of micro...     »
Zeitschriftentitel:
Nat Immunol
Jahr:
2022
Band / Volume:
23
Heft / Issue:
12
Seitenangaben Beitrag:
1749-1762
Volltext / DOI:
doi:10.1038/s41590-022-01360-6
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36456736
Print-ISSN:
1529-2908
TUM Einrichtung:
Molekulare Immunologie (Prof. Knolle)
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