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Titel:

Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Lutz, Konstantin; Musumeci, Andrea; Sie, Christopher; Dursun, Ezgi; Winheim, Elena; Bagnoli, Johannes; Ziegenhain, Christoph; Rausch, Lisa; Bergen, Volker; Luecken, Malte D; Oostendorp, Robert A J; Schraml, Barbara U; Theis, Fabian J; Enard, Wolfgang; Korn, Thomas; Krug, Anne B
Abstract:
Plasmacytoid and conventional dendritic cells (pDC and cDC) are generated from progenitor cells in the bone marrow and commitment to pDCs or cDC subtypes may occur in earlier and later progenitor stages. Cells within the CD11c+MHCII-/loSiglec-H+CCR9lo DC precursor fraction of the mouse bone marrow generate both pDCs and cDCs. Here we investigate the heterogeneity and commitment of subsets in this compartment by single-cell transcriptomics and high-dimensional flow cytometry combined with cell fa...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2022
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-022-31054-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/35705536
Print-ISSN:
2041-1723
TUM Einrichtung:
594; Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie; Molekulare Immunologie (Prof. Knolle)
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