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Document type:
journal article 
Author(s):
Lauffer, Felix; Jargosch, Manja; Krause, Linda; Garzorz-Stark, Natalie; Franz, Regina; Roenneberg, Sophie; Böhner, Alexander; Mueller, Nikola S; Theis, Fabian J; Schmidt-Weber, Carsten B; Biedermann, Tilo; Eyerich, Stefanie; Eyerich, Kilian 
Title:
Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis. 
Abstract:
Interface dermatitis is a characteristic histological pattern that occurs in autoimmune and chronic inflammatory skin diseases. It is unknown whether a common mechanism orchestrates this distinct type of skin inflammation. Here we investigated the overlap of two different interface dermatitis positive skin diseases, lichen planus and lupus erythematosus. The shared transcriptome signature pointed toward a strong type I immune response, and biopsy-derived T cells were dominated by IFN-? and tumor...    »
 
Journal title abbreviation:
J Invest Dermatol 
Year:
2018 
Journal volume:
138 
Journal issue:
Pages contribution:
1785-1794 
Language:
eng 
Print-ISSN:
0022-202X 
TUM Institution:
Institut für Molekulare Allergologie