Benutzer: Gast  Login
Titel:

IRF-1 SNPs influence the risk for childhood allergic asthma: A critical role for pro-inflammatory immune regulation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Landgraf-Rauf, Katja; Boeck, Andreas; Siemens, Diana; Klucker, Elisabeth; Vogelsang, Vanessa; Schmidt, Susanne; Kunze, Sonja; Weissenbacher, Claudia; Graessel, Anke; Schmidt-Weber, Carsten; von Mutius, Erika; Schedel, Michaela; Schaub, Bianca
Abstract:
BACKGROUND: Allergic and non-allergic childhood asthma has been characterized by distinct immune mechanisms. While interferon regulating factor 1 (IRF-1) polymorphisms (SNPs) influence atopy risk, the effect of SNPs on asthma phenotype-specific immune mechanisms is unclear. We assessed whether IRF-1 SNPs modify distinct immune-regulatory pathways in allergic and non-allergic childhood asthma (AA/NA). METHODS: In the CLARA study, asthma was characterized by doctor's diagnosis and AA vs NA by posi...     »
Zeitschriftentitel:
Pediatr Allergy Immunol
Jahr:
2018
Band / Volume:
29
Heft / Issue:
1
Seitenangaben Beitrag:
34-41
Sprache:
eng
Volltext / DOI:
doi:10.1111/pai.12821
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29047170
Print-ISSN:
0905-6157
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
 BibTeX