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Title:

Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3ROR?t Regulatory T Cells.

Document type:
Journal Article
Author(s):
Ogawa, Chihiro; Bankoti, Rashmi; Nguyen, Truc; Hassanzadeh-Kiabi, Nargess; Nadeau, Samantha; Porritt, Rebecca A; Couse, Michael; Fan, Xuemo; Dhall, Deepti; Eberl, Gerald; Ohnmacht, Caspar; Martins, Gislâine A
Abstract:
Foxp3 regulatory T cells (Treg) are essential modulators of immune responses, but the molecular mechanisms underlying their function are not fully understood. Here we show that the transcription factor Blimp-1 is a crucial regulator of the Foxp3ROR?t Treg subset. The intrinsic expression of Blimp-1 in these cells is required to prevent production of Th17-associated cytokines. Direct binding of Blimp-1 to the Il17 locus in Treg is associated with inhibitory histone modifications but unaltered bin...     »
Journal title abbreviation:
Cell Rep
Year:
2018
Journal volume:
25
Journal issue:
1
Pages contribution:
19-28.e5
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2018.09.016
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30282028
Print-ISSN:
2211-1247
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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