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Title:

Phosphatidylinositol 3-Kinase (PI3K) Orchestrates Aspergillus fumigatus-Induced Eosinophil Activation Independently of Canonical Toll-Like Receptor (TLR)/C-Type-Lectin Receptor (CLR) Signaling.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Dietschmann, Axel; Schruefer, Sebastian; Westermann, Stefanie; Henkel, Fiona; Castiglione, Kirstin; Willebrand, Ralf; Adam, Jasmin; Ruland, Jürgen; Lang, Roland; Sheppard, Donald C; Esser-von-Bieren, Julia; Radtke, Daniel; Krappmann, Sven; Voehringer, David
Abstract:
Eosinophilia is associated with various persisting inflammatory diseases and often coincides with chronic fungal infections or fungal allergy as in the case of allergic bronchopulmonary aspergillosis (ABPA). Here, we show that intranasal administration of live Aspergillus fumigatus conidia causes fatal lung damage in eosinophilic interleukin-5 (IL-5)-transgenic mice. To further investigate the activation of eosinophils by A. fumigatus, we established a coculture system of mouse bone marrow-deriv...     »
Journal title abbreviation:
MBio
Year:
2022
Journal volume:
13
Journal issue:
4
Fulltext / DOI:
doi:10.1128/mbio.01239-22
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/35695427
Print-ISSN:
2150-7511
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Lehrstuhl für Molekulare Allergologie und Umweltforschung (Prof. Schmidt-Weber)
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