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Title:

Type I Immune Response Induces Keratinocyte Necroptosis and Is Associated with Interface Dermatitis.

Document type:
Journal Article
Author(s):
Lauffer, Felix; Jargosch, Manja; Krause, Linda; Garzorz-Stark, Natalie; Franz, Regina; Roenneberg, Sophie; Böhner, Alexander; Mueller, Nikola S; Theis, Fabian J; Schmidt-Weber, Carsten B; Biedermann, Tilo; Eyerich, Stefanie; Eyerich, Kilian
Abstract:
Interface dermatitis is a characteristic histological pattern that occurs in autoimmune and chronic inflammatory skin diseases. It is unknown whether a common mechanism orchestrates this distinct type of skin inflammation. Here we investigated the overlap of two different interface dermatitis positive skin diseases, lichen planus and lupus erythematosus. The shared transcriptome signature pointed toward a strong type I immune response, and biopsy-derived T cells were dominated by IFN-? and tumor...     »
Journal title abbreviation:
J Invest Dermatol
Year:
2018
Journal volume:
138
Journal issue:
8
Pages contribution:
1785-1794
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jid.2018.02.034
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29526761
Print-ISSN:
0022-202X
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber); Professur für Experimentelle Dermato-Immunologie (Prof. Eyerich)
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