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Titel:

MEK1/2 regulates APOBEC3B and polymerase iota-induced mutagenesis in head and neck cancer cells.

Dokumenttyp:
Journal Article
Autor(en):
Schulz, Dominik; Piontek, Guido; Zissler, Ulrich M; Multhoff, Gabriele; Wirth, Markus; Pickhard, Anja
Abstract:
Resistance to chemotherapy provides a major challenge in treatment of metastatic cancer. Prolonged exposure to almost any drug regimen leads to the formation of resistant subclones in almost all advanced solid tumors. Tumor heterogeneity because of intrinsic genetic instability is seen as one of the major contributing factors. In this work, we present evidence that genetic instability measured by mutation frequency is induced by treatment with the EGFR inhibitor afatinib or cisplatin in head and...     »
Zeitschriftentitel:
Am J Cancer Res
Jahr:
2021
Band / Volume:
11
Heft / Issue:
11
Seitenangaben Beitrag:
5581-5590
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34873481
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie; Molekulare Allergologie (Prof. Schmidt-Weber)
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