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Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Xie, Kan; Fuchs, Helmut; Scifo, Enzo; Liu, Dan; Aziz, Ahmad; Aguilar-Pimentel, Juan Antonio; Amarie, Oana Veronica; Becker, Lore; da Silva-Buttkus, Patricia; Calzada-Wack, Julia; Cho, Yi-Li; Deng, Yushuang; Edwards, A Cole; Garrett, Lillian; Georgopoulou, Christina; Gerlini, Raffaele; Hölter, Sabine M; Klein-Rodewald, Tanja; Kramer, Michael; Leuchtenberger, Stefanie; Lountzi, Dimitra; Mayer-Kuckuk, Phillip; Nover, Lena L; Oestereicher, Manuela A; Overkott, Clemens; Pearson, Brandon L; Rathkolb,...     »
Titel:
Deep phenotyping and lifetime trajectories reveal limited effects of longevity regulators on the aging process in C57BL/6J mice.
Abstract:
Current concepts regarding the biology of aging are primarily based on studies aimed at identifying factors regulating lifespan. However, lifespan as a sole proxy measure for aging can be of limited value because it may be restricted by specific pathologies. Here, we employ large-scale phenotyping to analyze hundreds of markers in aging male C57BL/6J mice. For each phenotype, we establish lifetime profiles to determine when age-dependent change is first detectable relative to the young adult bas...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2022
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41467-022-34515-y
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/36369285
Print-ISSN:
2041-1723
TUM Einrichtung:
617; Molekulare Allergologie (Prof. Schmidt-Weber)
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