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Title:

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.

Document type:
Journal Article
Author(s):
Gruber, Tim; Pan, Chenchen; Contreras, Raian E; Wiedemann, Tobias; Morgan, Donald A; Skowronski, Alicja A; Lefort, Sandrine; De Bernardis Murat, Cahuê; Le Thuc, Ophelia; Legutko, Beata; Ruiz-Ojeda, Francisco J; Fuente-Fernández, María de la; García-Villalón, Angel Luis; González-Hedström, Daniel; Huber, Melanie; Szigeti-Buck, Klara; Müller, Timo D; Ussar, Siegfried; Pfluger, Paul; Woods, Steve C; Ertürk, Ali; LeDuc, Charles A; Rahmouni, Kamal; Granado, Miriam; Horvath, Tamas L; Tschöp, Matthias...     »
Abstract:
Pathologies of the micro- and macrovascular systems are a hallmark of the metabolic syndrome, which can lead to chronically elevated blood pressure. However, the underlying pathomechanisms involved still need to be clarified. Here, we report that an obesity-associated increase in serum leptin triggers the select expansion of the micro-angioarchitecture in pre-autonomic brain centers that regulate hemodynamic homeostasis. By using a series of cell- and region-specific loss- and gain-of-function m...     »
Journal title abbreviation:
Cell Metab
Year:
2021
Journal volume:
33
Journal issue:
6
Pages contribution:
1155-1170.e10
Fulltext / DOI:
doi:10.1016/j.cmet.2021.04.007
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33951475
Print-ISSN:
1550-4131
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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