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Title:

POMC neuronal heterogeneity in energy balance and beyond: an integrated view.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Author(s):
Quarta, Carmelo; Claret, Marc; Zeltser, Lori M; Williams, Kevin W; Yeo, Giles S H; Tschöp, Matthias H; Diano, Sabrina; Brüning, Jens C; Cota, Daniela
Abstract:
Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of the body's energy status, since they act in an opposite manner to modulate appetite and systemic energy metabolism. However, although AgRP neurons' functions are comparatively well understood, a unifying theory of how POMC neuronal cells operate has remained elusive, probably due to their high level of heterogeneity, which suggests that their physiological roles might be more complex than initially thought. In th...     »
Journal title abbreviation:
Nat Metab
Year:
2021
Journal volume:
3
Journal issue:
3
Pages contribution:
299-308
Fulltext / DOI:
doi:10.1038/s42255-021-00345-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33633406
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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