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Titel:

Anti-obesity drug discovery: advances and challenges.

Dokumenttyp:
Journal Article; Review
Autor(en):
Müller, Timo D; Blüher, Matthias; Tschöp, Matthias H; DiMarchi, Richard D
Abstract:
Enormous progress has been made in the last half-century in the management of diseases closely integrated with excess body weight, such as hypertension, adult-onset diabetes and elevated cholesterol. However, the treatment of obesity itself has proven largely resistant to therapy, with anti-obesity medications (AOMs) often delivering insufficient efficacy and dubious safety. Here, we provide an overview of the history of AOM development, focusing on lessons learned and ongoing obstacles. Recent...     »
Zeitschriftentitel:
Nat Rev Drug Discov
Jahr:
2022
Band / Volume:
21
Heft / Issue:
3
Seitenangaben Beitrag:
201-223
Volltext / DOI:
doi:10.1038/s41573-021-00337-8
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34815532
Print-ISSN:
1474-1776
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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