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Professur für Biopolymermaterialien (Prof. Lieleg)
2017
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Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Winkeljann, Benjamin; Käsdorf, Benjamin T.; Boekhoven, Job; Lieleg, Oliver
Titel:
Macromolecular Coating Enables Tunable Selectivity in a Porous PDMS Matrix
Abstract:
Whether for laboratory use or clinical practice, many fields in Life Sciences require selective filtering. However, most existing filter systems lack the ability to easily tune their filtration behavior. Two key elements for efficient filtering are a high surface-to-volume ratio and the presence of suitable chemical groups which establish selectivity. In this study, an artificial PDMS-based capillary system with highly tunable selectivity properties is presented. The high surface-to-volume ratio of this filter system is generated by first embedding sugar fibers into a synthetic polymer matrix and then dissolving these fibers from the cured polymer. To functionalize this filter, the inner surface of the capillaries is coated with purified or synthetic macromolecules. Depending on the type of macromolecule used for filter functionalization, selective sieving is observed based on steric hindrance, electrostatic binding, electrostatic repulsion, or specific binding interactions. Furthermore, it is demonstrated that enzymes can be immobilized in the capillary system which allows for performing multiple cycles of enzymatic reactions with the same batch of enzymes and without the need to separate the enzymes from their reaction products. In addition to lab-scale filtration and enzyme immobilization applications demonstrated here, the functionalized porous PDMS matrix may also be used to test binding interactions between different molecules. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Stichworte:
PDMS; bio-macromolecules; mucin; separation
Dewey Dezimalklassifikation:
500 Naturwissenschaften
Zeitschriftentitel:
Macromolecular Bioscience
Jahr:
2017
Seitenangaben Beitrag:
1700311
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1002/mabi.201700311
WWW:
https://www.researchgate.net/publication/322024941_Macromolecular_Coating_Enables_Tunable_Selectivity_in_a_Porous_PDMS_Matrix
Verlag / Institution:
Wiley-Blackwell
E-ISSN:
1616-5187
Publikationsdatum:
22.12.2017
TUM Einrichtung:
Fachgebiet für Biomechanik
BibTeX
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mediaTUM Gesamtbestand
Hochschulbibliographie
2017
Fakultäten
Maschinenwesen
Professur für Biomechanik (Prof. Lieleg)
mediaTUM Gesamtbestand
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Schools
TUM School of Engineering and Design
Departments
Materials Engineering
Professur für Biopolymermaterialien (Prof. Lieleg)
2017