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Titel:

Preclinical to phase II amyloid beta (A) peptide modulators under investigation for Alzheimer's disease.

Dokumenttyp:
Journal Article; Review
Autor(en):
Parsons, Chris G; Rammes, Gerhard
Abstract:
Alzheimer disease (AD) is the most common form of dementia and its incidence is increasing at an alarming rate all over the world. The pathophysiology of AD is characterized by chronic, progressive neurodegeneration which involves early synaptotoxicity. One of the most obvious pathological feature of AD is the accumulation of amyloid-? (A?) in the brain. Since current treatment options only provide symptomatic help and A? is thought to underlie early synaptic pathology, A? reduction or modulatio...     »
Zeitschriftentitel:
Expert Opin Investig Drugs
Jahr:
2017
Band / Volume:
26
Heft / Issue:
5
Seitenangaben Beitrag:
579-592
Sprache:
eng
Volltext / DOI:
doi:10.1080/13543784.2017.1313832
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28362514
Print-ISSN:
1354-3784
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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