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Titel:

Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Prager, Matthias; Durmus, Tahir; Büttner, Janine; Molnar, Tamas; de Jong, Dirk J; Drenth, Joost Ph; Baumgart, Daniel C; Sturm, Andreas; Farkas, Klaudia; Witt, Heiko; Büning, Carsten
Abstract:
Myosin IXb (MYO9B) is involved in the regulation of epithelial barrier function. We hypothesized that MYO9B variants are associated with increased intestinal permeability measured in patients with Crohn's disease (CD), where barrier dysfunction is crucially involved in disease development.We sequenced MYO9B and genotyped five MYO9B variants (rs1545620, rs1457092, rs2279003, rs2305764 and rs2279002) and correlated these data to measurement of intestinal permeability in German CD patients (n = 122...     »
Zeitschriftentitel:
Scand J Gastroenterol
Jahr:
2014
Band / Volume:
49
Heft / Issue:
10
Seitenangaben Beitrag:
1191-200
Sprache:
eng
Volltext / DOI:
doi:10.3109/00365521.2014.928903
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25098938
Print-ISSN:
0036-5521
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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