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Title:

Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Prager, Matthias; Durmus, Tahir; Büttner, Janine; Molnar, Tamas; de Jong, Dirk J; Drenth, Joost Ph; Baumgart, Daniel C; Sturm, Andreas; Farkas, Klaudia; Witt, Heiko; Büning, Carsten
Abstract:
Myosin IXb (MYO9B) is involved in the regulation of epithelial barrier function. We hypothesized that MYO9B variants are associated with increased intestinal permeability measured in patients with Crohn's disease (CD), where barrier dysfunction is crucially involved in disease development.We sequenced MYO9B and genotyped five MYO9B variants (rs1545620, rs1457092, rs2279003, rs2305764 and rs2279002) and correlated these data to measurement of intestinal permeability in German CD patients (n = 122...     »
Journal title abbreviation:
Scand J Gastroenterol
Year:
2014
Journal volume:
49
Journal issue:
10
Pages contribution:
1191-200
Language:
eng
Fulltext / DOI:
doi:10.3109/00365521.2014.928903
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25098938
Print-ISSN:
0036-5521
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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