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Title:

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Claussnitzer, Melina; Dankel, Simon N; Klocke, Bernward; Grallert, Harald; Glunk, Viktoria; Berulava, Tea; Lee, Heekyoung; Oskolkov, Nikolay; Fadista, Joao; Ehlers, Kerstin; Wahl, Simone; Hoffmann, Christoph; Qian, Kun; Rönn, Tina; Riess, Helene; Müller-Nurasyid, Martina; Bretschneider, Nancy; Schroeder, Timm; Skurk, Thomas; Horsthemke, Bernhard; Spieler, Derek; Klingenspor, Martin; Seifert, Martin; Kern, Michael J; Mejhert, Niklas; Dahlman, Ingrid; Hansson, Ola; Hauck, Stefanie M; Blüher, Matth...     »
Abstract:
Genome-wide association studies have revealed numerous risk loci associated with diverse diseases. However, identification of disease-causing variants within association loci remains a major challenge. Divergence in gene expression due to cis-regulatory variants in noncoding regions is central to disease susceptibility. We show that integrative computational analysis of phylogenetic conservation with a complexity assessment of co-occurring transcription factor binding sites (TFBS) can identify c...     »
Journal title abbreviation:
Cell
Year:
2014
Journal volume:
156
Journal issue:
1-2
Pages contribution:
343-58
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2013.10.058
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24439387
Print-ISSN:
0092-8674
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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