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Title:

The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer.

Document type:
Journal Article
Author(s):
Wang, Kun; Demir, Ihsan Ekin; D'Haese, Jan G; Tieftrunk, Elke; Kujundzic, Kristina; Schorn, Stephan; Xing, Baocai; Kehl, Timo; Friess, Helmut; Ceyhan, Güralp O
Abstract:
Neurotrophic factors possess an emerging role in the pathophysiology of several gastrointestinal disorders, regulating innervation, pain sensation and disease-associated neuroplasticity. Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-derived neurotrophic factor receptor alpha-2 (GFR?-2) in pancreatic cancer (PCa) and pancreatic neuropathy. For this purpose, NRTN and GFR?-2 were studied in normal human pancreas and PCa tissue...     »
Journal title abbreviation:
Carcinogenesis
Year:
2014
Journal volume:
35
Journal issue:
1
Pages contribution:
103-13
Language:
eng
Fulltext / DOI:
doi:10.1093/carcin/bgt312
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24067900
Print-ISSN:
0143-3334
TUM Institution:
Chirurgische Klinik und Poliklinik
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