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Title:

Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Arnold-Schrauf, Catharina; Dudek, Markus; Dielmann, Anastasia; Pace, Luigia; Swallow, Maxine; Kruse, Friederike; Kühl, Anja A; Holzmann, Bernhard; Berod, Luciana; Sparwasser, Tim
Abstract:
Listeria monocytogenes (LM), a facultative intracellular Gram-positive pathogen, can cause life-threatening infections in humans. In mice, the signaling cascade downstream of the myeloid differentiation factor 88 (MyD88) is essential for proper innate immune activation against LM, as MyD88-deficient mice succumb early to infection. Here, we show that MyD88 signaling in dendritic cells (DCs) is sufficient to mediate the protective innate response, including the production of proinflammatory cytok...     »
Journal title abbreviation:
Cell Rep
Year:
2014
Journal volume:
6
Journal issue:
4
Pages contribution:
698-708
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2014.01.023
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24529704
Print-ISSN:
2211-1247
TUM Institution:
Chirurgische Klinik und Poliklinik
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