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Title:

Multimodal molecular imaging of integrin ?v?3 for in vivo detection of pancreatic cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Trajkovic-Arsic, Marija; Mohajerani, Pouyan; Sarantopoulos, Athanasios; Kalideris, Evdokia; Steiger, Katja; Esposito, Irene; Ma, Xiaopeng; Themelis, George; Burton, Neal; Michalski, Christoph W; Kleeff, Jörg; Stangl, Stefan; Beer, Ambros J; Pohle, Karolin; Wester, Hans-Jürgen; Schmid, Roland M; Braren, Rickmer; Ntziachristos, Vasilis; Siveke, Jens T
Abstract:
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease. Late detection of then nonresectable or metastasized tumors emphasizes the need for novel imaging approaches. Here, we report on so far nonexploited potentials of ?v?3 integrin-targeted molecular imaging technologies for detection of PDAC using genetically engineered mouse models.Immunohistochemistry and Western blot were used for characterization of ?v?3 expression in murine and human PDAC. We applied IntegriSense 680 fluorescence mol...     »
Journal title abbreviation:
J Nucl Med
Year:
2014
Journal volume:
55
Journal issue:
3
Pages contribution:
446-51
Language:
eng
Fulltext / DOI:
doi:10.2967/jnumed.113.129619
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24549287
Print-ISSN:
0161-5505
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für Nuklearmedizin; Lehrstuhl für Biologische Bildgebung - Zusammenarbeit mit dem Helmholtz-Zentrum München (Prof. Ntziachristos)
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