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Titel:

Hsp70--a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck.

Dokumenttyp:
Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Gehrmann, Mathias; Specht, Hanno M; Bayer, Christine; Brandstetter, Markus; Chizzali, Barbara; Duma, Marciana; Breuninger, Stephanie; Hube, Kathrin; Lehnerer, Sophie; van Phi, Valerie; Sage, Eva; Schmid, Thomas E; Sedelmayr, Michael; Schilling, Daniela; Sievert, Wolfgang; Stangl, Stefan; Multhoff, Gabriele
Abstract:
Tumor but not normal cells frequently overexpress heat shock protein 70 (Hsp70) and present it on their cell surface (mHsp70) from where it can be actively released. Therefore, membrane (mHsp70) and soluble Hsp70 (sHsp70) were investigated as potential tumor biomarkers and for monitoring the outcome of radiation therapy.Biopsies and blood were collected from patients with squamous cell carcinoma of the head and neck (SCCHN) at different time points (before, during therapy and in the follow-up pe...     »
Zeitschriftentitel:
Radiat Oncol
Jahr:
2014
Band / Volume:
9
Seitenangaben Beitrag:
131
Sprache:
eng
Volltext / DOI:
doi:10.1186/1748-717X-9-131
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24912482
Print-ISSN:
1748-717X
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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