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Title:

Primary glioblastoma cultures: can profiling of stem cell markers predict radiotherapy sensitivity?

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lemke, Dieter; Weiler, Markus; Blaes, Jonas; Wiestler, Benedikt; Jestaedt, Leonie; Klein, Ann-Catherine; Löw, Sarah; Eisele, Günter; Radlwimmer, Bernhard; Capper, David; Schmieder, Kirsten; Mittelbronn, Michel; Combs, Stephanie E; Bendszus, Martin; Weller, Michael; Platten, Michael; Wick, Wolfgang
Abstract:
Human glioblastomas may be hierarchically organized. Within this hierarchy, glioblastoma-initiating cells have been proposed to be more resistant to radiochemotherapy and responsible for recurrence. Here, established stem cell markers and stem cell attributed characteristics such as self-renewal capacity and tumorigenicity have been profiled in primary glioblastoma cultures to predict radiosensitivity. Furthermore, the sensitivity to radiotherapy of different subpopulations within a single prima...     »
Journal title abbreviation:
J Neurochem
Year:
2014
Journal volume:
131
Journal issue:
2
Pages contribution:
251-64
Language:
eng
Fulltext / DOI:
doi:10.1111/jnc.12802
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24976529
Print-ISSN:
0022-3042
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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