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Titel:

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy.

Dokumenttyp:
Journal Article; Review; Research Support, Non-U.S. Gov't; Review
Autor(en):
Gaipl, Udo S; Multhoff, Gabriele; Scheithauer, Heike; Lauber, Kirsten; Hehlgans, Stefanie; Frey, Benjamin; Rödel, Franz
Abstract:
Besides the direct, targeted effects of ionizing irradiation (x-ray) on cancer cells, namely DNA damage and cell death induction, indirect, nontargeted ones exist, which are mediated in large part by the immune system. Immunogenic forms of tumor cell death induced by x-ray, including immune modulating danger signals like the heat shock protein 70, adenosine triphosphate, and high-mobility group box 1 protein are presented. Further, antitumor effects exerted by cells of the innate (natural killer...     »
Zeitschriftentitel:
Immunotherapy
Jahr:
2014
Band / Volume:
6
Heft / Issue:
5
Seitenangaben Beitrag:
597-610
Sprache:
eng
Volltext / DOI:
doi:10.2217/imt.14.38
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24896628
Print-ISSN:
1750-743X
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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