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Title:

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy.

Document type:
Journal Article; Review; Research Support, Non-U.S. Gov't; Review
Author(s):
Gaipl, Udo S; Multhoff, Gabriele; Scheithauer, Heike; Lauber, Kirsten; Hehlgans, Stefanie; Frey, Benjamin; Rödel, Franz
Abstract:
Besides the direct, targeted effects of ionizing irradiation (x-ray) on cancer cells, namely DNA damage and cell death induction, indirect, nontargeted ones exist, which are mediated in large part by the immune system. Immunogenic forms of tumor cell death induced by x-ray, including immune modulating danger signals like the heat shock protein 70, adenosine triphosphate, and high-mobility group box 1 protein are presented. Further, antitumor effects exerted by cells of the innate (natural killer...     »
Journal title abbreviation:
Immunotherapy
Year:
2014
Journal volume:
6
Journal issue:
5
Pages contribution:
597-610
Language:
eng
Fulltext / DOI:
doi:10.2217/imt.14.38
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24896628
Print-ISSN:
1750-743X
TUM Institution:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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