Fear of recurrence and its impact on quality of life in patients with hematological cancers in the course of allogeneic hematopoietic SCT.

Sarkar, S; Scherwath, A; Schirmer, L; Schulz-Kindermann, F; Neumann, K; Kruse, M; Dinkel, A; Kunze, S; Balck, F; Kröger, N; Koch, U; Mehnert, A

doi:10.1038/bmt.2014.139

2014

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Document type:: Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):: Sarkar, S; Scherwath, A; Schirmer, L; Schulz-Kindermann, F; Neumann, K; Kruse, M; Dinkel, A; Kunze, S; Balck, F; Kröger, N; Koch, U; Mehnert, A
Title:: Fear of recurrence and its impact on quality of life in patients with hematological cancers in the course of allogeneic hematopoietic SCT.
Abstract:: We examined the course and the prevalence of a high fear of cancer recurrence (FCR) in patients undergoing allogeneic PBSC transplantation (hematopoietic SCT (HSCT)) before HSCT (N=239), 100 days after (n=150, and 12 months after allogeneic HSCT (n=102). The Fear of Progression Questionnaire-Short Form (FoP-Q-SF), the EORTC Quality of Life Questionnaire, and the Hospital Anxiety and Depression Scale were used. Pre-HSCT 36% of patients, 100 days after HSCT 24% of patients, and 1 year after HSCT 23% of patients fulfilled the criteria for high FCR (FoP-Q-SF cutoff=34). Being married (b=2.76, P=0.026), female gender (b=4.45, P<0.001) and depression (b=4.44, P<0.001) were significantly associated with FCR at baseline. One hundred days after HSCT, depression significantly predicted FCR (b=6.46, P<0.001). One year following HSCT, female gender (b=6.61, P=0.008) and higher depression were (b=4.88, P=0.004) significant predictors for FCR. Over the three assessment points, patients with high FCR had a significantly lower quality of life compared to patients with low FCR in physical functioning (P=0.019), role functioning (P=0.003), emotional functioning (P<0.001), cognitive functioning (P=0.003), social functioning (P<0.001) and global quality of life (P<0.001). Our data provide evidence that FCR is a prevalent problem in patients with hematological malignancies and has a significant adverse impact on health-related quality of life.
Journal title abbreviation:: Bone Marrow Transplant
Year:: 2014
Journal volume:: 49
Journal issue:: 9
Pages contribution:: 1217-22
Language:: eng
Fulltext / DOI:: doi:10.1038/bmt.2014.139
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/25000458
Print-ISSN:: 0268-3369
TUM Institution:: Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie (Prof. Henningsen)2014