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Titel:

Inhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Illert, Anna L; Seitz, Anna K; Rummelt, Christoph; Kreutmair, Stefanie; Engh, Richard A; Goodstal, Samantha; Peschel, Christian; Duyster, Justus; von Bubnoff, Nikolas
Abstract:
ABL tyrosine kinase inhibitors (TKI) like Imatinib, Dasatinib and Nilotinib are the gold standard in conventional treatment of CML. However, the emergence of resistance remains a major problem. Alternative therapeutic strategies of ABL TKI-resistant CML are urgently needed. We asked whether dual inhibition of BCR-ABL and Aurora kinases A-C could overcome resistance mediated by ABL kinase mutations. We therefore tested the dual ABL and Aurora kinase inhibitors PHA-739358 and R763/AS703569 in Ba/F...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2014
Band / Volume:
9
Heft / Issue:
11
Seitenangaben Beitrag:
e112318
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0112318
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25426931
Print-ISSN:
1932-6203
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Urologische Klinik und Poliklinik
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