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Titel:

A Multicenter Phase 1 Study of EMD 525797 (DI17E6), a Novel Humanized Monoclonal Antibody Targeting ?v Integrins, in Progressive Castration-resistant Prostate Cancer with Bone Metastases After Chemotherapy.

Dokumenttyp:
Journal Article
Autor(en):
Wirth, Manfred; Heidenreich, Axel; Gschwend, Jürgen E; Gil, Thierry; Zastrow, Stefan; Laniado, Michael; Gerloff, Joachim; Zühlsdorf, Michael; Mordenti, Giacomo; Uhl, Wolfgang; Lannert, Heinrich
Abstract:
EMD 525797 (DI17E6) is a deimmunized, humanized monoclonal immunoglobulin G2 antibody against the ?v subunit of human integrins. Blocking ?v integrins may be an effective strategy for inhibiting prostate cancer (PCa) metastasis.Evaluate EMD 525797 safety/tolerability and pharmacokinetics (PK) in castration-resistant PCa patients. Secondary objectives included antitumor activity assessments.A phase 1 open-label study in 26 patients (four European centers). Eligible patients (>=18 yr) had histolog...     »
Zeitschriftentitel:
Eur Urol
Jahr:
2014
Band / Volume:
65
Heft / Issue:
5
Seitenangaben Beitrag:
897-904
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.eururo.2013.05.051
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23791392
Print-ISSN:
0302-2838
TUM Einrichtung:
Urologische Klinik und Poliklinik
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