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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Yamada, Elizabeth S; Respondek, Gesine; Müssner, Stefanie; de Andrade, Anderson; Höllerhage, Matthias; Depienne, Christel; Rastetter, Agnès; Tarze, Agathe; Friguet, Bertrand; Salama, Mohamed; Champy, Pierre; Oertel, Wolfgang H; Höglinger, Günter U
Titel:
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Abstract:
Both genetic and environmental factors likely contribute to the neuropathology of tauopathies, but it remains unclear how specific genetic backgrounds affect the susceptibility towards environmental toxins. Mutations in the tau gene have been associated with familial tauopathies, while annonacin, a plant-derived mitochondrial inhibitor, has been implicated in an environmental form of tauopathy. We therefore determined whether there was a pathogenic synergy between annonacin exposure and the expr...     »
Zeitschriftentitel:
Exp Neurol
Jahr:
2014
Band / Volume:
253
Seitenangaben Beitrag:
113-25
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.expneurol.2013.12.017
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24389273
Print-ISSN:
0014-4886
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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