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Titel:

Towards the generation of B-cell receptor retrogenic mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Freitag, Jenny; Heink, Sylvia; Roth, Edith; Wittmann, Jürgen; Jäck, Hans-Martin; Kamradt, Thomas
Abstract:
Transgenic expression of B- and T-cell receptors (BCRs and TCRs, respectively) has been a standard tool to study lymphocyte development and function in vivo. The generation of transgenic mice is time-consuming and, therefore, a faster method to study the biology of defined lymphocyte receptors in vivo would be highly welcome. Using 2A peptide-linked multicistronic retroviral vectors to transduce stem cells, TCRs can be expressed rapidly in mice of any background. We aimed at adopting this retrog...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2014
Band / Volume:
9
Heft / Issue:
10
Seitenangaben Beitrag:
e109199
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0109199
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25296340
Print-ISSN:
1932-6203
TUM Einrichtung:
Neurologische Klinik und Poliklinik
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