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Titel:

MR-based hypoxia measures in human glioma.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Tóth, V; Förschler, A; Hirsch, NM; den Hollander, J; Kooijman, H; Gempt, J; Ringel, F; Schlegel, J; Zimmer, C; Preibisch, C
Abstract:
Hypoxia plays a central role in tumor stem cell genesis and is related to a more malignant tumor phenotype, therapy resistance (e.g. in anti-angiogenic therapies) and radio-insensitivity. Reliable hypoxia imaging would provide crucial metabolic information in the diagnostic work-up of brain tumors. In this study, we applied a novel BOLD-based MRI method for the measurement of relative oxygen extraction fraction (rOEF) in glioma patients and investigated potential benefits and drawbacks. Forty-fi...     »
Zeitschriftentitel:
J Neurooncol
Jahr:
2013
Band / Volume:
115
Heft / Issue:
2
Seitenangaben Beitrag:
197-207
Sprache:
eng
Volltext / DOI:
doi:10.1007/s11060-013-1210-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23918147
Print-ISSN:
0167-594X
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); Institut für Allgemeine Pathologie und Pathologische Anatomie; Neurochirurgische Klinik und Poliklinik
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