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Titel:

Hypoxia upregulates aldehyde dehydrogenase isoform 1 (ALDH1) expression and induces functional stem cell characteristics in human glioblastoma cells.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Soehngen, Eric; Schaefer, Andrea; Koeritzer, Julia; Huelsmeyer, Velia; Zimmer, Claus; Ringel, Florian; Gempt, Jens; Schlegel, Juergen
Abstract:
Aldehyde dehydrogenase 1 (ALDH1) has been used to isolate tumorigenic stem-like cells in a large number of tumors, including glioblastoma multiforme (GBM). We recently showed that human glioblastoma cells with high ALDH1 (ALDH1(high)) activity contain stem-cell-like characteristics. In the study reported here, we isolated established and primary human glioblastoma cells based on their ALDH1 expression. When tested for asymmetric division, only cells with ALDH1(high) expression were able to resto...     »
Zeitschriftentitel:
Brain Tumor Pathol
Jahr:
2014
Band / Volume:
31
Heft / Issue:
4
Seitenangaben Beitrag:
247-56
Sprache:
eng
Volltext / DOI:
doi:10.1007/s10014-013-0170-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24197864
Print-ISSN:
1433-7398
TUM Einrichtung:
Fachgebiet Neuroradiologie (Prof. Zimmer); Neurochirurgische Klinik und Poliklinik
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