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Title:

Premature Terminal Differentiation Protects from Deregulated Lymphocyte Activation by ITK-Syk.

Document type:
Journal Article; Article
Author(s):
Bach, Martina P; Hug, Eva; Werner, Markus; Holch, Julian; Sprissler, Clara; Pechloff, Konstanze; Zirlik, Katja; Zeiser, Robert; Dierks, Christine; Ruland, Jürgen; Jumaa, Hassan
Abstract:
The development of hematopoietic neoplasms is often associated with mutations, altered gene expression or chromosomal translocations. Recently, the t(5, 9)(q33; q22) translocation was found in a subset of peripheral T cell lymphomas and was shown to result in an IL-2-inducible kinase-spleen tyrosine kinase (ITK-Syk) fusion transcript. In this study, we show that T cell-specific expression of the ITK-Syk oncogene in mice leads to an early onset and aggressive polyclonal T cell lymphoproliferation...     »
Journal title abbreviation:
J Immunol
Year:
2014
Journal volume:
192
Journal issue:
3
Pages contribution:
1024-33
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1300420
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24376268
Print-ISSN:
0022-1767
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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