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Title:

B-cell expansion and lymphomagenesis induced by chronic CD40 signaling is strictly dependent on CD19.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hojer, Caroline; Frankenberger, Samantha; Strobl, Lothar J; Feicht, Samantha; Djermanovic, Kristina; Jagdhuber, Franziska; Hömig-Hölzel, Cornelia; Ferch, Uta; Ruland, Jürgen; Rajewsky, Klaus; Zimber-Strobl, Ursula
Abstract:
CD40, a member of the TNF receptor family, is expressed on all mature B cells and on most B-cell lymphomas. Recently, we have shown that constitutive activation of CD40 signaling in B cells induced by a fusion protein consisting of the transmembrane part of the Epstein-Barr viral latent membrane protein 1 (LMP1) and the cytoplasmic part of CD40 (LMP1/CD40) drives B-cell lymphoma development in transgenic mice. Because LMP1/CD40-expressing B cells showed an upregulation of CD19, we investigated C...     »
Journal title abbreviation:
Cancer Res
Year:
2014
Journal volume:
74
Journal issue:
16
Pages contribution:
4318-28
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-13-3274
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24938766
Print-ISSN:
0008-5472
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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