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Title:

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1? production.

Document type:
Journal Article; Research Support, N.I.H., Extramural
Author(s):
Roth, Susanne; Rottach, Andrea; Lotz-Havla, Amelie S; Laux, Verena; Muschaweckh, Andreas; Gersting, Søren W; Muntau, Ania C; Hopfner, Karl-Peter; Jin, Lei; Vanness, Katelynd; Petrini, John H J; Drexler, Ingo; Leonhardt, Heinrich; Ruland, Jürgen
Abstract:
Double-stranded DNA (dsDNA) in the cytoplasm triggers the production of interleukin 1? (IL-1?) as an antiviral host response, and deregulation of the pathways involved can promote inflammatory disease. Here we report a direct cytosolic interaction between the DNA-damage sensor Rad50 and the innate immune system adaptor CARD9. Transfection of dendritic cells with dsDNA or infection of dendritic cells with a DNA virus induced the formation of dsDNA-Rad50-CARD9 signaling complexes for activation of...     »
Journal title abbreviation:
Nat Immunol
Year:
2014
Journal volume:
15
Journal issue:
6
Pages contribution:
538-45
Language:
eng
Fulltext / DOI:
doi:10.1038/ni.2888
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24777530
Print-ISSN:
1529-2908
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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