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- Title:
Inflammasome: putting the pieces together.
- Document type:
- Comment; Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Ruland, Jürgen
- Abstract:
- Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.
- Journal title abbreviation:
- Cell
- Year:
- 2014
- Journal volume:
- 156
- Journal issue:
- 6
- Pages contribution:
- 1127-9
- Language:
- eng
- Fulltext / DOI:
- doi:10.1016/j.cell.2014.02.038
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/24630715
- Print-ISSN:
- 0092-8674
- TUM Institution:
- Institut für Klinische Chemie und Pathobiochemie
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