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Title:

Inflammasome: putting the pieces together.

Document type:
Comment; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Ruland, Jürgen
Abstract:
Microbial and danger signals result in inflammasome activation and release of inflammatory cytokines through mechanisms that remain elusive. Cai et al. and Lu et al. show that triggering of inflammasome sensors induces prion-like polymerization of the adaptor ASC into filaments. These structures function as platforms for inflammatory cytokine production and represent a unified mechanism for inflammasome assembly.
Journal title abbreviation:
Cell
Year:
2014
Journal volume:
156
Journal issue:
6
Pages contribution:
1127-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cell.2014.02.038
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24630715
Print-ISSN:
0092-8674
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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