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Title:

Bcl10 mediates angiotensin II-induced cardiac damage and electrical remodeling.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Marko, Lajos; Henke, Norbert; Park, Joon-Keun; Spallek, Bastian; Qadri, Fatimunnisa; Balogh, Andras; Apel, Ingrid J; Oravecz-Wilson, Katherine I; Choi, Mira; Przybyl, Lukasz; Binger, Katrina J; Haase, Nadine; Wilck, Nicola; Heuser, Arnd; Fokuhl, Verena; Ruland, Jürgen; Lucas, Peter C; McAllister-Lucas, Linda M; Luft, Friedrich C; Dechend, Ralf; Müller, Dominik N
Abstract:
Angiotensin (Ang) II is a potent mediator of both hypertension and cardiac damage; however, the mechanisms by which this occur remain unclear. B-cell lymphoma/leukemia 10 (Bcl10) is a member of the CBM signalosome, which links Ang II and nuclear factor-?B signaling. We hypothesized that Bcl10 is pivotal in the pathogenesis of Ang II-induced cardiac damage. Ang II infusion in mice lacking Bcl10 resulted in reduced cardiac fibrosis, less cellular infiltration, and improved arrhythmogenic electric...     »
Journal title abbreviation:
Hypertension
Year:
2014
Journal volume:
64
Journal issue:
5
Pages contribution:
1032-9
Language:
eng
Fulltext / DOI:
doi:10.1161/HYPERTENSIONAHA.114.03900
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25185127
Print-ISSN:
0194-911X
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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