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Title:

Falsely elevated cyclosporin and tacrolimus concentrations over prolonged periods of time due to reversible adsorption to central venous catheters.

Document type:
Journal Article; Article
Author(s):
Hacker, Charlotte; Verbeek, Mareike; Schneider, Heike; Steimer, Werner
Abstract:
Falsely elevated concentrations of immunosuppressants can be caused by reversible adsorption to central venous catheter (CVC) systems. If undetected, this may lead to dose reduction resulting in underdosage which may even entail graft-versus-host disease or organ rejection. We analyzed the adsorption and release for cyclosporine A (CsA) and tacrolimus (Tac) in vitro and in vivo. Four types of CVCs were examined in vitro: two made from polyurethane (PU), one from silicone and one from PU with an...     »
Journal title abbreviation:
Clin Chim Acta
Year:
2014
Journal volume:
433
Pages contribution:
62-8
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cca.2014.02.031
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24631133
Print-ISSN:
0009-8981
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
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