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Title:

Detection of NF-?B pathway activation in T helper cells.

Document type:
Journal Article
Author(s):
Gorka, Oliver; Wanninger, Stefan; Ruland, Jürgen
Abstract:
Upon activation of CD4+ T helper cells the transcription factor complex NF-?B becomes activated and its subunits are able to translocate to the nucleus. There, the dimerized proteins regulate the transcription of for example cytokine and pro-survival genes. This process is of central importance for a proper function of T helper cells as its loss causes severe immunodeficiency, whereas its deregulation can contribute to lymphomagenesis or autoimmunity. In this protocol we describe four methods to...     »
Journal title abbreviation:
Methods Mol Biol
Year:
2014
Journal volume:
1193
Pages contribution:
69-83
Language:
eng
Fulltext / DOI:
doi:10.1007/978-1-4939-1212-4_8
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25150998
Print-ISSN:
1064-3745
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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