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Titel:

Impaired motor cortex plasticity in patients with Noonan syndrome.

Dokumenttyp:
Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Mainberger, Florian; Zenker, Martin; Jung, Nikolai H; Delvendahl, Igor; Brandt, Antonia; Freudenberg, Leonie; Heinen, Florian; Mall, Volker
Abstract:
Noonan syndrome (NS; OMIM 163950) is a developmental disorder caused by activating mutations in various components of the RAS-MAPK pathway. Recent in vitro studies demonstrated impairment of synaptic plasticity caused by RAS-MAPK pathway hyperactivity. Induction of synaptic plasticity critically depends on the level of attention. We therefore studied the induction of synaptic plasticity in patients with NS and healthy volunteers under different conditions of attention using transcranial magneti...     »
Zeitschriftentitel:
Clin Neurophysiol
Jahr:
2013
Band / Volume:
124
Heft / Issue:
12
Seitenangaben Beitrag:
2439-44
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.clinph.2013.04.343
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23763990
Print-ISSN:
1388-2457
TUM Einrichtung:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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