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Title:

Lovastatin improves impaired synaptic plasticity and phasic alertness in patients with neurofibromatosis type 1.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Mainberger, Florian; Jung, Nikolai H; Zenker, Martin; Wahlländer, Ute; Freudenberg, Leonie; Langer, Susanne; Berweck, Steffen; Winkler, Tobias; Straube, Andreas; Heinen, Florian; Granström, Sofia; Mautner, Victor-Felix; Lidzba, Karen; Mall, Volker
Abstract:
Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders causing learning disabilities by mutations in the neurofibromin gene, an important inhibitor of the RAS pathway. In a mouse model of NF1, a loss of function mutation of the neurofibromin gene resulted in increased gamma aminobutyric acid (GABA)-mediated inhibition which led to decreased synaptic plasticity and deficits in attentional performance. Most importantly, these defictis were normalized by lovastatin. This placebo...     »
Journal title abbreviation:
BMC Neurol
Year:
2013
Journal volume:
13
Pages contribution:
131
Language:
eng
Fulltext / DOI:
doi:10.1186/1471-2377-13-131
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24088225
Print-ISSN:
1471-2377
TUM Institution:
Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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