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Titel:

The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Grünewald, Thomas G P; Willier, Semjon; Janik, Dirk; Unland, Rebekka; Reiss, Cora; Prazeres da Costa, Olivia; Buch, Thorsten; Dirksen, Uta; Richter, Günther H S; Neff, Frauke; Burdach, Stefan; Butt, Elke
Abstract:
Ewing's sarcoma (ES) is the second most common bone-associated malignancy in children and is driven by the fusion oncogene EWS/FLI1 and characterised by rapid growth and early metastasis. Here, we explored the role of the Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) in ES. The Zyxin family comprises seven homologous proteins involved in migration and proliferation of many cell types of which Zyxin has been described as a tumour suppressor in ES.By interrogation of publish...     »
Zeitschriftentitel:
Biol Cell
Jahr:
2013
Band / Volume:
105
Heft / Issue:
11
Seitenangaben Beitrag:
535-47
Sprache:
eng
Volltext / DOI:
doi:10.1111/boc.201300041
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24033704
Print-ISSN:
0248-4900
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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