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Title:

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation.

Document type:
Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Article
Author(s):
Schlenk, Richard F; Kayser, Sabine; Bullinger, Lars; Kobbe, Guido; Casper, Jochen; Ringhoffer, Mark; Held, Gerhard; Brossart, Peter; Lübbert, Michael; Salih, Helmut R; Kindler, Thomas; Horst, Heinz A; Wulf, Gerald; Nachbaur, David; Götze, Katharina; Lamparter, Alexander; Paschka, Peter; Gaidzik, Verena I; Teleanu, Veronica; Späth, Daniela; Benner, Axel; Krauter, Jürgen; Ganser, Arnold; Döhner, Hartmut; Döhner, Konstanze
Abstract:
The objective was to evaluate the prognostic and predictive impact of allelic ratio and insertion site (IS) of internal tandem duplications (ITDs), as well as concurrent gene mutations, with regard to postremission therapy in 323 patients with FLT3-ITD-positive acute myeloid leukemia (AML). Increasing FLT3-ITD allelic ratio (P = .004) and IS in the tyrosine kinase domain 1 (TKD1, P = .06) were associated with low complete remission (CR) rates. After postremission therapy including intensive chem...     »
Journal title abbreviation:
Blood
Year:
2014
Journal volume:
124
Journal issue:
23
Pages contribution:
3441-9
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2014-05-578070
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25270908
Print-ISSN:
0006-4971
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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