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Title:

cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent manner.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Wong, W Wei-Lynn; Vince, James E; Lalaoui, Najoua; Lawlor, Kate E; Chau, Diep; Bankovacki, Aleksandra; Anderton, Holly; Metcalf, Donald; O'Reilly, Lorraine; Jost, Philipp J; Murphy, James M; Alexander, Warren S; Strasser, Andreas; Vaux, David L; Silke, John
Abstract:
Loss of inhibitor of apoptosis proteins (IAPs), particularly cIAP1, can promote production of tumor necrosis factor (TNF) and sensitize cancer cell lines to TNF-induced necroptosis by promoting formation of a death-inducing signaling complex containing receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3. To define the role of IAPs in myelopoiesis, we generated a mouse with cIAP1, cIAP2, and XIAP deleted in the myeloid lineage. Loss of cIAPs and XIAP in the myeloid lineage caused...     »
Journal title abbreviation:
Blood
Year:
2014
Journal volume:
123
Journal issue:
16
Pages contribution:
2562-72
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2013-06-510743
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24497535
Print-ISSN:
0006-4971
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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