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Title:

MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Westmeyer, Gil G; Emer, Yelena; Lintelmann, Jutta; Jasanoff, Alan
Abstract:
The ability to map patterns of gene expression noninvasively in living animals could have impact in many areas of biology. Reporter systems compatible with MRI could be particularly valuable, but existing strategies tend to lack sensitivity or specificity. Here we address the challenge of MRI-based gene mapping using the reporter enzyme secreted alkaline phosphatase (SEAP), in conjunction with a water-soluble metalloporphyrin contrast agent. SEAP cleaves the porphyrin into an insoluble product t...     »
Journal title abbreviation:
Chem Biol
Year:
2014
Journal volume:
21
Journal issue:
3
Pages contribution:
422-9
Language:
eng
Fulltext / DOI:
doi:10.1016/j.chembiol.2014.01.012
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24613020
Print-ISSN:
1074-5521
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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